What is Chronic Kidney Disease? – What is Chronic Kidney Disease (CKD)?    – Facts about Chronic Kidney Disease    – What are the symptoms of Chronic Kidney Disease?    – What are the risk factors for Chronic Kidney Disease ?    – What causes Chronic Kidney Disease?    – How is vitamin D involved in Chronic Kidney Disease? – How does Rocaltrol work in Patients with Chronic Kidney Disease?    – How should I take Rocaltrol?    – How will my physician know whether my treatment with Rocaltrol is working? Chronic kidney disease is the gradual damage to your kidneys which decreases their ability to keep you healthy by clearing the bloodstream of waste products. If kidney disease gets worse, wastes can build to high levels in your blood and make you feel sick. You may develop complications like high blood pressure, anemia (low blood count), weak bones, poor nutritional health, and nerve damage. Also, kidney disease increases your risk of having heart and blood vessel disease. These problems may happen slowly over a long period of time. Chronic kidney disease may be caused by diabetes, high blood pressure, and other disorders. Early detection and treatment can often keep chronic kidney disease from getting worse. When kidney disease progresses, it may eventually lead to kidney failure, which requires dialysis or a kidney transplant to maintain life. References: 1. National Kidney Foundation: Chronic Kidney Disease (CKD), National Kidney Foundation Web site. Available at: http://www.kidney.org/kidneydisease/ckd/index.cfm. © March 2010 Validus Pharmaceuticals LLC. All rights reserved. ROC-014-09

Full Prescribing Information for Rocaltrol Important Safety Information for Rocaltrol® (calcitriol) Capsules and Oral solution Rocaltrol should not be taken if there are symptoms of abnormally elevated vitamin D or calcium levels or if you are allergic to any product ingredient. Taking too much vitamin D can cause high calcium levels, which could trigger serious health problems and may require immediate medical attention. Dosage adjustments of Rocaltrol may be required if other medications are initiated or discontinued; do not stop taking other medications without your physician's knowledge. Potential side effects of Rocaltrol are, in general, similar to effects of taking too much vitamin D. Report early symptoms of elevated vitamin D or calcium including weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle or bone pain, metallic taste, and anorexia, abdominal pain or stomach ache, to your doctor.